Silicon particles as trojan horses for potential cancer therapy
نویسندگان
چکیده
BACKGROUND Porous silicon particles (PSiPs) have been used extensively as drug delivery systems, loaded with chemical species for disease treatment. It is well known from silicon producers that silicon is characterized by a low reduction potential, which in the case of PSiPs promotes explosive oxidation reactions with energy yields exceeding that of trinitrotoluene (TNT). The functionalization of the silica layer with sugars prevents its solubilization, while further functionalization with an appropriate antibody enables increased bioaccumulation inside selected cells. RESULTS We present here an immunotherapy approach for potential cancer treatment. Our platform comprises the use of engineered silicon particles conjugated with a selective antibody. The conceptual advantage of our system is that after reaction, the particles are degraded into soluble and excretable biocomponents. CONCLUSIONS In our study, we demonstrate in particular, specific targeting and destruction of cancer cells in vitro. The fact that the LD50 value of PSiPs-HER-2 for tumor cells was 15-fold lower than the LD50 value for control cells demonstrates very high in vitro specificity. This is the first important step on a long road towards the design and development of novel chemotherapeutic agents against cancer in general, and breast cancer in particular.
منابع مشابه
Clostridial spores as live 'Trojan horse' vectors for cancer gene therapy: comparison with viral delivery systems
Solid tumours account for 90% of all cancers. Gene therapy represents a potential new modality for their treatment. Up to now, several approaches have been developed, but the most efficient ones are the viral vector based gene therapy systems. However, viral vectors suffer from several deficiencies: firstly most vectors currently in use require intratumoural injection to elicit an effect. This ...
متن کاملEvent-Based Method for Detecting Trojan Horses in Mobile Devices
Mobile phones and wireless technology and its constant evolution have, in the last years, revolutionized the way in which we communicate and work. However, one of the main barriers encounter in the use of these technologies is data security. Trojan horses are dangerous software to attack phones, PDAs and Smartphones. New versions are created everyday to attack the functionality, theft the store...
متن کاملSecure FPGA Design by Filling Unused Spaces
Nowadays there are different kinds of attacks on Field Programmable Gate Array (FPGA). As FPGAs are used in many different applications, its security becomes an important concern, especially in Internet of Things (IoT) applications. Hardware Trojan Horse (HTH) insertion is one of the major security threats that can be implemented in unused space of the FPGA. This unused space is unavoidable to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2014